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Dr. Heba Elsayed Abd Elhaliam Baioumy :: Publications: |
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| Title: | Berberine chloride loaded nano-PEGylated liposomes
attenuates imidacloprid-induced neurotoxicity by
inhibiting NLRP3/Caspase-1/GSDMD-mediated pyroptosis |
| Authors: | Walaa Bayoumie El Gazzar1,2 | Amina A. Farag3 | Mohamed Samir4,5 | Heba Bayoumi6 | Heba S. Youssef |
| Year: | 2024 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Heba Elsayed Abd Elhaliam Baioumy_PAPER 8.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Concerns have been expressed about imidacloprid (IMI), one of the most often used pesticides, and its potential neurotoxicity to non-target organisms. Chronic neuroinflammation is central to the pathology of several neurodegenerative disorders. Hence, exploring the molecular mechanism by which IMI would trigger neuroinflammation is particularly important. This study examined the neurotoxic effects of oral administration of IMI (45 mg/kg/day for 30 days) and the potential neuroprotective effect of berberine (Ber) chloride loaded nano-PEGylated liposomes (Ber-Lip) (10 mg/kg, intravenously every other day for 30 days) using laboratory rat. The histopathological changes, anti-oxidant and oxidative stress markers (GSH, SOD, and MDA), |
