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Dr. Heba Mohamed Rashad :: Publications:

Title:
Significance of SIRT1 and Claudin 4 Expression in Gastric Carcinoma:An Immunohistochemical study
Authors: Heba Mohamed Rashad
Year: 2016
Keywords: Gastric carcinoma, SIRT1,Claudin 4
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Heba Mohamed Rashad_abstract.docx
Supplementary materials Not Available
Abstract:

Background:SIRT1 and claudin4 have been implicated in tumorigenesis in many cancers, but their significance in gastric carcinoma remains unclear. The aim of this study is to assess their possible significance in gastric carcinoma Methods:Immunohistochemistry was performed to examine the expression of SIRT1 and claudin4 in 68 casesof gastric carcinoma and 3 adjacent precursor lesions (chronic gastritis, intestinal metaplasia and dysplasia).Statistical analysis methods were used to evaluate the relationship between SIRT1 and claudin4 and various clinicopathological parameters. Results: SIRT1 and claudin4 were found highly expressed in gastric carcinoma.The two markers significantly correlated with depth of tumor invasion,distant metastasis and TNM stage.SIRT1 was positively correlated with advanced tumor grade while claudin4 was inversely correlated with it. No significant correlation between SIRT1 and claudin4 was detected. Conclusions: The results suggested that both SIRT1 and Claudin 4 might be involved in gastric carcinogenesis. The more advanced TNM GC stage, thehigher expression of SIRT1 and claudin 4suggesting their possible role in gastric carcinoma progression.

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