Background: postmenopausal osteoporosis is associated with significant morbidity, mortality and reduction in quality of life. Aim of this study was to evaluate the impact of a designed educational program on the quality of life for postmenopausal women with osteoporosis. It hypothesized that postmenopausal women with osteoporosis who will receive an educational program will have improved quality of life. Quasi-experimental design (pre and post intervention) was utilized to fulfill the aim of this study. A total sample of (118) a primary osteoporosis (type I) women in absence of fracture, and free from any other chronic diseases or medical conditions known to affect bone were recruited in the study. The study was conducted at two settings; orthopedic clinic at Benha University Hospital and rheumatoid clinic at Benha Teaching Hospital. Data were collected through three main tools: structured interviewing questionnaire, health practices of osteoporosis sheet (designed by the researcher), and osteoporosis quality of life questionnaire (The ECOS-16) (Badia et al., 2000). The procedure passed through four phases; assessment, planning, implementation and follow up and evaluation, it took place during the period of one year started at October, 2008 and ended at September, 2009. Results: the meanSD of age was 57.773.23 years, mean age of menopause was 48.281.83 years, and time elapsed since menopause was 9.482.21 years. A significant improvement in the studied women’ knowledge and practice after implementation of educational program and follow up periods p value |