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Dr. Hend El Sayed Nasr El sayed :: Publications:

Title:
Ameliorative efects of sildenafl against carbon tetrachloride induced hepatic fbrosis in rat model through downregulation of osteopontin gene expression
Authors: Hend Elsayed Nasr1 , Ahmed Medhat Hegazy 2*, Noha Osama El‑Shaer3 , Rabab Shaban El‑shafey4 , SalwaA. Elgendy5 , HebaA. Elnoury5 , Walaa Bayoumie ElGazzar1 & LinaAbdelhady Mohammed1
Year: 2024
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Hend El Sayed Nasr El sayed _41598_2024_Article_67305.pdf
Supplementary materials Not Available
Abstract:

The liver carries out many essential tasks, such as synthesising cholesterol, controlling the body’s storage of glycogen, and detoxifying metabolites, in addition to performing, and regulating homeostasis. Hepatic fbrosis is a pathological state characterized by over accumulation of extracellular matrix (ECM) including collagen fbers. Sildenafl (a selective inhibitor of type 5 phosphodiesterase) has antiinfammatory, antioxidant and antiapoptotic properties. It is commonly used to treat erectile dysfunction in male. The purpose of the current investigation was to evaluate sildenafl’s hepatoprotective potential against liver fbrosis in rats that was caused by carbon tetrachloride (CCl4). Liver enzymes and oxidative markers as well as profbrotic genes were determined. The fndings showed that sildenafl alleviates the hepatic dysfunctions caused by CCl4 by restoring normal levels of ALT, AST, and GGT as well as by restoring the antioxidant status demonstrated by increased glutathione (GSH), and catalase. In addition, a signifcantly down regulated the mRNA expressions of profbrotic genes [collagen1α, IL1β, osteopontin (OPN), and transforming growth factorβ (TGFβ)]. Additionally, sildenafl lessens the periportal fbrosis between hepatic lobules, congestion and dilatation in the central vein, and the infammatory cell infltrations. As a result, it is hypothesized that sildenafl may be helpful in the management of hepatotoxicity brought on by CCl4 through suppressing OPN.

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