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Prof. Hussein Dory Abd Alghafar Abaza :: Publications:

The role of HIF1a, VEGFa and MCT4 on performance in racing horses.
Authors: A. Behairy, Hussein A. Heshmat, Hussein Abaza
Year: 2017
Keywords: HIF 1 α , VEGF α and MCT4
Journal: Life Science Journal
Volume: 14
Issue: 9
Pages: 11
Publisher: Acta Zhengzhou University
Local/International: International
Paper Link: Not Available
Full paper Hussein Dory Abd Alghafar Abaza_The role of HIF1a VEgfa and MCT4 on performance in racing horses.pdf
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Abstract: For several decades, equine physical performance has been a subject of research; just some studies have been directed for molecular genetic analyses. To date, examines in people have reported several genes related with elite athletic performance , while thinks about in horses are uncommon. In our research we aimed to illustrate the role of certain genes which linked with exercise and training, and have been revealed to be functionally relevant for early performance assessment of elite athletic horses. Ten racing horses (5 Arabian and 5 T horoughbred horses ) were s elected from equestrian clubs in Cairo Governorate. Firstly, physical parameters included (heart rate and temperature) were detected. Then, the blood samples obtained from both groups before and instantly after tra ining from trained horses. Quantitative real time PCR used to measure HIF 1 α, VEGFα and MCT4 gene expression. Our results reported a considerable increase in HIF 1 α, VEGFα and MCT4 gene expression after training in trained horses. The results determine d the pivotal role of HIF 1 α, VEGFα and MCT4 in exercise and their important effect on equine performance during hypoxic training. In conclusion, t his study interprets underlying molecular responses to exercise and training adaptations in equine blood and how these responses affect on system - wide physiological performance. B iology of the HIF 1 pathway a nd other related genes affecting horse performance have seen great interest . Despite late great evolution in understanding the atomic instruments of the HIF pathw ay because of its activity, several important questions still need ed to be answered .

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