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Prof. Hussein Abd Elmaksoud Ali :: Publications:

Title:
Biochemical effect of some novel nanocomposite on metabolic changes in experimentally induced tumor in female mice
Authors: omayma A.R. abou zaid, Abd El-Maksoud Hussein A., Abdel-Fattah M Badawi, Mohammed F El-Sheikha, Mohammed A. Hussein
Year: 2016
Keywords: Curcumin nanoparticles, Zinc Oxide nanoparticles (ZnNP), Vitamin C, CTAB, ALT, AST,Creatinine, Urea, NO, IL-6, IL-8.
Journal: International journal of pharma sciences
Volume: 6
Issue: 4
Pages: 1587-1593
Publisher: aizeon publishers
Local/International: International
Paper Link:
Full paper Hussein Abd Elmaksoud Ali_16.pdf
Supplementary materials Not Available
Abstract:

ABSTRACT Nanoparticles have one dimension that measures 100 nanometers or less. The properties of many conventional materials will be changed when they are in nanoparticle form. This is typically because nanoparticles have a greater surface area per weight than larger particles which make them to be more reactive to other molecules. The aim of this study to demonstrate the biochemical effect of basic curcumin – zinc oxide nanocomposite modified with vitamin C and surfactant induced experimentally in female mice. This study was carried out on 80 mice and weighted 25-30 gm. Blood samples were collected from all animals groups after 2, 4 and 6 weeks of treatment. Serum were separated and processed directly for (AST and ALT) activities, (Urea, Creatinine, Nitric oxide) concentration and Interleukin-6 (IL-6) and Interleukin-8 (IL-8) levels. The obtained results revealed that, these the novel nanocomposite have a very important role in improving liver & kidney functions and pro inflammatory agents.

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