Liver acts as a cornerstone in most biotransformation process. CCl4 is one of the most common chemicals producing liver injury. Liquorice is a medicinal plant widely consumed in egypt as a juice. In our study we aimed to estimate the hepatoprotective effect of liquorice crude extract against CCL4-induced hepatitis in rats and to clarify its underlying molecular mechanism through its effect on inflammatory biomarkers and antioxidant system. To achieve our objective a sixty male albino rats were divided into 6 groups, normal control group, hepatitis group, hepatitis group treated with low conc. liquorice extract, hepatitis group treated with high conc. liquorice extract, normal group with low conc. liquorice extract and normal group with high conc. liquorice extract. The outcome of the study exhibits a representative association between exposure to CCl4 and alteration of liver function parameters and hematological profile and elucidate the hepatoprotective effect of liquorice extract through its anti-inflammatory and antioxidant properties. |
