This study was done to investigate the ameliorative effect of parsley extract and/or alfacalcidol on KBrO3
induced nephrotoxicity in rats. Fifty rats were classified into 5 groups: Group 1: (normal control group): rats
injected once with normal saline I/P. Group 2: (nephrotoxic group) rats injected with single dose of KBrO3
(130 mg/kg B.wt, I/P). Group 3:(parsley extract treated group) rats received KBrO3 then after 3 days treated
with parsley extract at a dose of (400 mg/kg.b.wt /day/6 weeks ) orally. Group 4 (alfacalcidol treated group)
rats injected once with KBrO3 at a dose of (130 mg/kg B.wt, I/P) and after 3 days treated with alfacalcidol at
a dose of (0. 2µg /day / 6 weeks.) orally. Group 5:(parsley extract plus alfacalcidol treated group) rats
injected once with by KBrO3 at a dose of ( 130 mg/kg B.wt, I/P) and after 3 days treated with both of parsley
extract (400mg/kg b.wt/day/6 weeks) and alfacalcidol (0.2µg/ day / 6 weeks) orally. Our results showed that
rats injected with pot. Bromate revealed a significant increase in serum creatinine activity, urea, uric, and
potassium concentration in addition to increase of MPO, NO and MDA concentration in renal tissue on the
other hand, a significant decrease in serum sodium concentration and renal tissue (SOD and GPx) were
observed. Treatment with parsley extract or alfacalcidol or their combination revealed decrease in serum
creatinine, urea, uric, potassium, MPO, NO renal tissue MDA, on the other hand, significant increase in
serum sodium level and renal tissue SOD, GPx activities were observed. Parsley extract or alfacalcidol act as
a potentially promising agent used to treat nephrotoxicity. Parsley extract may be a novel natural products
for management of nephrotoxicity |
