A total number of fifty one cases suffering from different surgical affections of the perineum and vagina were recorded. The recorded affections were mainly perineal, vulvar and/or vaginal neoplasms and perineal lacera-tions. However, other affections either congenital (as rectovaginal fistula and /or atresia ani) or acquired (Vaginal or uterine prolapse and Bartholin's gland cyst) were also recorded. Neoplastic masses of the perineum, vulva and va-gina were recorded in twenty animals (7 cows, 6 goats, 2 mares, 3 donkeys, a buffalo, and one ewe). In cattle, squamous cell carcinoma was identified in 5 cows, while vaginal lipoma as well as vulvar fibrosarcoma was identi-fied in only one cow. The only recorded mass in buffaloes was perineal fibrosarcoma. Out of the six neoplasms identified in the perineum in goats, 5 were melanomas, and only one was squamous cell carcinoma. In sheep, the only recorded mass was squamous cell carcinoma. While both of squamous cell carcinoma and melanoma were recorded equally in horses (one case each), the identified masses in donkeys were fibroma (two cases) and fibrosarcoma (one case). The clinical symptoms, surgery, recurrence and metastasis of these masses were studied and discussed. Third degree laceration was recorded in six animals (4 mares and 2 cows) and corrected by using the modified Goetze technique of the single stage repair (Interrupted six-bite vertical mattress pattern). The surgical outcome was recorded and interpretated. Some other conditions as Bartholin gland cyst (one case), atresia ani with or without rectovaginal fistula (5 cases), vaginal prolapse (5 cases), uterine prolapse (4 cases) and wounds and lacerations (10 cases) were also recorded.