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Dr. Howaida Elkholy :: Publications:

Clonidine in horses, identification, detection and clinical pharmacology
Authors: Dirikolu L, McFadden ET, Ely KJ, ElkHoly H, Lehner AF, Thompson K
Year: 2006
Keywords: Not Available
Journal: Veterinary Therapeutics
Volume: 7
Issue: 2
Pages: 141-155
Publisher: Publisher: Veterinary Learning Systems Co
Local/International: International
Paper Link:
Full paper Howaida Elkholy_chlonidine detection.pdf
Supplementary materials Not Available

Clonidine is classified as a class 3 performance-enhancing agent by the Asso-ciation of Racing Commissioners International and thus has the potential to in-fluence the outcome of a race. In this study, the authors developed and validat-ed a sensitive gas chromatograph and mass spectrometer method to determinethe pharmacokinetic parameters of clonidine in equine plasma samples after IVadministration of a single dose (0.025 mg/kg) of clonidine in horses. At thisdose, clonidine produced rapid and profound sedation, which could be quicklyreversed with yohimbine. Clonidine was able to produce an analgesic effect butfailed to provide maximal analgesia in all horses; the limited analgesic effectpersisted for about 60 minutes

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