Bisphenol A (BPA) is a worldwide used endocrine disruptor that is incorporated in many plastic industries. The exposure of humans to such substance starts early during the fetal life. Many agencies raised warnings against the excessive use of such substances. The present study aimed to evaluate the oxidative stress effect of BPA on liver and kidney of albino rats, and whether co-administration of vitamin C can ameliorate this oxidative damage. Albino rats were divided into three groups: control group, BPA treated group, and BPA+ vitamin C treated group. The oxidative stress arising from BPA was evaluated in liver and kidney tissues. In addition, serum creatinine, uric acid levels, (AST) and (ALT) activities as markers of kidney and liver function were measured. Biochemical analysis revealed significant reduction in activities of enzymatic antioxidants in BPA treated group and BPA + vitamin C treated group as compared to control group. In addition, there were significant increase in AST, ALT, uric acid, and creatinine levels in BPA treated group and BPA + vitamin C treated group as compared to control group. Histopathological and ultrastructure changes of liver and kidney were observed in BPA treated group and BPA + vitamin C treated group as compared to control group. The present study demonstrated that BPA could induce hepato & nephrotoxicity, affecting oxidant/antioxidant balance in rat liver and kidney. In addition, co-administration of vitamin C with BPA augments this oxidative damage. |
