A 20- week experiment on laying hens was carried out to examine the effects of feeding graded levels of FB 1 on performance, chemical parameters, antibody titers to Newcastle disease virus in serum and histopathological changes in different organs. The graded levels of FB1 are 100 mg FB1/kg diet (group2); 200 mg FB1/kg diet (group 3) and 400 mg FB1/kg diet (group 4), while group 1 fed diet uncontaminated with FB 1. Each group included 16 hens. The laying intensity and egg weight during the course of experiment were lower in hens of groups 2, 3 and 4 than hens of group 1. The body weight during the experimental period was lower in only hens of group 4 (fed on 400 mg FBI/kg diet) compared to those of groups 1, 2 and 3. A significant increase in aspartate aminotransferase, alanine aminotransferase, cholesterol, uric acid and creatinine in FB1 treated groups compared to control one. While there was no significant changes in the level of the tumor marker Alphafetoprotein (AFP) in FB1 treated groups compared to control one. Hens in groups 2, 3 and 4 have a significant decrease in serum titers to NDV. Histopathological changes revealed thickening in the wall of blood vessels in different organs, fatty infiltration in heart and gizzard. Degeneration in proventriculus, nephrotoxic and hepatotoxic changes were also found in FB1 treated groups.
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