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Dr. maee afifi nasr mohammed nasr :: Publications:

Serum Ghrelin level in patients with type2 Diabetes Mellitus
Authors: Maee Afifi Nasr , Akeel Abdelazem Hefni, Mohammed Yehia Seddik, Mohammed Shawki Al- Sayed, Ahmed Mahmoud Saleh .
Year: 2018
Keywords: Ghrelin; Type ΙΙ diabetes; Insulin resistance; Body mass Index
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper maee afifi nasr mohammed nasr_REVIEW MAEE(GHRELIN AND DM)3.docx
Supplementary materials Not Available

Background: Recent studies on ghrelin in type 2 diabetes mellitus and its interactions with insulin are controversial. Clarifying such hormonal interplay in type 2 diabetes could be helpful in control and treatment of the disease. Aim: to study the serum level of ghrelin in patients with type 2 diabetes mellitus, show the effect of glycemic control on ghrelin and study the relationship between ghrelin with components of metabolic syndrome. Methods: 90 subjects were enrolled in two groups, 70 with T2DM and 20 controls. Blood glucose values, HbA1c, insulin, lipid profile, creatinine, liver enzymes and total ghrelin were measured. HOMA-IR and eGFR were calculated. Results: Ghrelin was negatively correlated with BMI, WC, SBP, DBP, FBG, PPBG, triglyceride, total cholesterol, LDL-C, HbA1c, insulin, HOMA-IR, UACR and eGFR and positively correlated with HDL-C and creatinine in diabetic group. Ghrelin was significantly decreased in diabetic patients with severe insulin resistance, poor glycemic control and vascular complications. Conclusion: It can be concluded that low ghrelin level is an indicator of adverse consequences in diabetic patients suggesting that ghrelin antagonism may improve β-cell function.

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