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Dr. magdy eldesouky :: Publications:

Title:
Letrozole induction of ovulation in clomiphene citrate resistant polycystic ovary syndrome: responders and non-responders
Authors: Aboubakr Elnashar, M.D. Magdy Eldosoky, M.D. Hany Fouad, M.D. Naser Abelgafar, M.S.
Year: 2004
Keywords: Not Available
Journal: Middle East Fertility Society Journal
Volume: 29
Issue: 2
Pages: Not Available
Publisher: Middle East Fertility Society Journal
Local/International: International
Paper Link: Not Available
Full paper magdy eldesouky_papers magdi.docx
Supplementary materials Not Available
Abstract:

Objective: To evaluate the efficacy of Letrozole in induction of ovulation in cases of CC-resistant PCOS and to compare between Letrozole responders and non-responders. Design: Prospective trial in infertility patients treated with CC Setting: Benha University Hospital Clinic, Egypt. Patient(s): Forty-four infertile women with anovulatory PCOS who failed to ovulate with CC. Intervention(s): Letrozole was given in a dose of 2.5 mg/day from day 3 to day 7 of the menstrual cycle. When the dominant follicle reached a diameter > 18 mm, HCG 10.000 U was given and timed intercourse was advised. Main outcome measure(s): Occurrence of ovulation, endomertial thickness, cervical score & pregnancy rate Results: On the day of HCG administration, the mean number of follicles > 18mm was 1.21, the mean endometrial thickness was 10.2 mm and cervical mucus score was 11.42. Ovulation occurred in 24 cases (54.6%) and pregnancy in 6 cases (25%). There was no significant difference between Letrozole responders and non-responders as regards the age, period of infertility, BMI, waist circumference, LH, FS H or LH/FSH ratio.

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