You are in:Home/Publications/Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links

Dr. maha mahmoud :: Publications:

Title:
Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links
Authors: Amina A. Farag, Heba S. Youssef, Rania E. Sliem , Walaa Bayoumie El Gazzar , Nashwa Nabil , Maha M. Mokhtar,Yasmin M. Marei , Nesma S. Ismail , Shaimaa E. Radwaan , Amira M. Badr, Alaa El-Din Hamid Sayed
Year: 2023
Keywords: Not Available
Journal: Toxicology. 2023: 15:492:153545
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper maha mahmoud_paper 4.pdf
Supplementary materials Not Available
Abstract:

Background: Microplastics (MPs) pollution is a newly emerging environmental issue. MPs can accumulate within animals and humans, which can pose a serious health threat. Petroleum-based polyethylene (PE) is one of the most popular plastics. Accordingly, its exposure rates have steadily increased over the years. Aim of the work: This study aimed to analyze the effects of PE-MPs on the hematological system of albino rats and the epigenetic effect. Material and methods: Five groups of adult male eight-weeks-old rats received either distilled water, corn oil, 3.75 mg/kg PE-MPs, 15 mg/kg PE-MPs, or 60 mg/kg of PE-MPs, daily by oral gavage for 35 days. Results: PE-MPs significantly increased the body weights of the rats and lipid peroxidation, with concomitant reduction of superoxide dismutase activity and depletion of reduced glutathione, thus adversely affecting oxidants/antioxidants balance. Moreover, PE-MPs increased the % of abnormal RBCs, irregular cells, tear drop cells, Schistocyte cells, and folded cells. The genotoxic effects on DNA were evident by increased DNA damage, confirmed by the comet assay, in addition to increased DNA methylation. The effects of PE-MPs have been shown to be dose correlated. Conclusion: this study provides evidence of dose-related PE MPs-induced hematological, genotoxic, and epigenetic effects in mammals, and thus emphasizes the potentially hazardous health effects of environmental PE-MPs.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus