Background: Polycystic ovary syndrome (PCOS) is a
hormonal disorder common among women of reproductive
age and affects over than 10% of these women. The hormonal
derangement associated with PCOS is uniformly characterized
by excess androgens and abnormal insulin activity.
Aim of Study: Estimation of serum levels of spexin (SPX)
in women with polycystic ovary syndrome (PCOS) who had
non-alcoholic fatty liver disease (NAFLD) and to evaluate its
relation to the diagnostic markers of both diseases.
Patients and Methods: 102 PCOS women with NAFLD
were evaluated clinically and by ultrasound for estimation of
ovarian size and determination of liver steatosis grade. Blood
samples were obtained for estimation of serum SPX, testosterone, dehydroepiandrosterone sulfate (DHEA-S), lipid
profile, aspartate transaminase (AST) and alanine transaminase
(ALT) and the AST/ALT ratio (AAR) was calculated.
Results: All women showed significantly high serum
testosterone, DHEA-S, blood lipid profile with high homeostasis model assessment of IR (HOMA-IR) score, while showed
significantly lower serum SPX levels than control women.
Sixty-nine women had ovarian size of >10cm
3
, and 36 and
5 patients had steatosis of grade 1 and 2, respectively. Serum
SPX levels showed negative significant correlations with liver
steatosis grade, HOMA-IR, ovarian size, BMI, serum testosterone, TG, TC and AAR; while showed positive significant
correlation with serum HDL-c. Liver steatosis grade showed
positive significant correlation with serum testosterone, ovarian
size, BMI, AAR, HOMA-IR score, serum levels of DHEAS, lipids. Regression analysis defined low SPX, high testosterone, LDL-c and DHEA-S levels are for high liver steatosis
grade in PCOS women.
Conclusion: Serum SPX concentrations were significantly
decreased in patients had PCOS and NAFLD and was correlated with their associated disturbances. Spexin could be
considered as the cornerstone for regulation of the relation
between PCOS and NAFLD. |
