The present study is done to evaluate the plasma levels of resistin in patients with type II diabetes in an attempt to explore its role in type II diabetes mellitus. The study was performed on 80 individuals categorized as follow: twenty apparently healthy adults as a control group, sixty type 2 diabetic patients. All the studied individuals were subjected to full history taking and clinical examination. In the present study, the association of plasma resistin level is investigated (by ELISA), with variable parameters: age, BMI, fasting and post prandial blood glucose, blood urea, serum creatinine, glycated Hb, serum insulin and insulin resistance by HOMA-R, -cell function by HOMA- and insulin sensitivity by QUICKI. The result of this study revealed non-significant differences in plasma resistin levels between diabetics and controls. There was no statistically significant difference between males and females in both diabetics and controls as regard plasma resistin levels. Also, there was no statistically significant difference as regard plasma resistin levels in normal weight, overweight or obese diabetic subjects. Moreover, there was no statistically significant correlation between plasma resistin levels and all the studied parameters in both diabetics and controls. In conclusion, this study revealed that plasma resistin may not be involved in the pathogenesis of insulin resistance, obesity and or type II D.M. However, further studies are needed, on a wider scale for further evaluation of the relation of resistin to the components of metabolic syndrome. |
