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Dr. mahmoud.hamada :: Publications:

Title:
Prevalence of secondary hyperparathyroidism among patients with diabetic nephropathy 2
Authors: Not Available
Year: 2018
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper mahmoud.hamada_shpt dn.pdf
Supplementary materials Not Available
Abstract:

Introduction 29 Both secondary hyperparathyroidism and diabetes mellitus have increased the risk for cardiovascular complication. 30 The prevalence of SHPT among diabetic nephropathy patients is not previously studied. The aim of this study to 31 evaluate the prevalence of SHPT among diabetic nephropathy patients attended to diabetes and nephrology 32 outpatient clinic. 33 Patients and methods: 34 In this retrospective study, 437 diabetic patients were enrolled in this study from 864 diabetic patients who attended 35 diabetes and nephrology outpatient clinics in our tertiary care hospital in Jeddah from Jan 2014 to Feb 2017. 36 Inclusion criteria were: [1] Age ≥18 years, [2] Patient had diabetic nephropathy which was diagnosed based on the 37 presence of urinary albumin/creatinine ratio (uACR) ≥ 30 mg/gm. Exclusion criteria were|: [1] patients were already 38 receiving cinacalcet and/or[2] patients had undergone neck surgery for parathyroidectomy. The intact parathyroid 39 hormone, 25 vitamin D level, uACR results were obtained from patients’ medical records. Patients were divided 40 into two groups: those with euparathyroidism (an iPTH level less than 65 pg/mL) and those with 41 hyperparathyroidism with iPTH level above or equal to 66 pg/mL. 42 Results: 43 Three hundred and seventy-four patients (85.5%) had an iPTH level above normal. We found a significant mean 44 difference between the two groups regarding uACR, eGFR, and serum urea. Our results showed that SHPT group 45 2 had a statistically significant lower level of vitamin D and serum calcium. Furthermore, we found that there was a 46 strong correlation between iPTH level and serum creatinine, eGFR, UACR, vitamin D. 47 Conclusion: 48 SHPT is common among diabetic nephropathy patients. 49 KEYWORDS: 50 SHPT; diabetic nephropathy; vitamin D

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