Abstract
The free energy of transfer (ΔGtr) of salicylic acid from water to N,N-dimethylformamide (DMF) and their mixtures was calculated from the solubilities of salicylic acid in different H2O—DMF mixtures. The maximum value of ΔGtr was found to be −7.008 kcal for pure DMF. In addition to ΔGtr calculations, the values of the association constant (Kass) of salicylic acid were calculated from the acid concentration (solubility, S) and the pH values of the saturated solution. The highest Kass value was found to be 1016.16 in pure DMF.
Moreover, the free energies of H-bonding of salicylic acid in these mixtures were calculated from the values of ΔGtr and its individual terms (ΔGsum). |
