Abstract: Background: Acute myocardial infarction (AMI) is caused by the interruption of blood supply to a portion of the heart, which causes heart cells to die. Aim of the present study is to investigate the potential role of NAC in MI and detect the role of oxidative stress markers, and inflammatory markers (IL-6 and TNF-α. Materials and methods: 32 male Wistar rats were divided into four groups, each comprising eight animals (n=8): a control group (Group 1) was maintained in typical control circumstances and given a balanced diet; NAC group (group II), Rats will be orally treated with NAC (10 mg/kg) dissolved in saline daily for a period of 14 days. ISO group (group III) The animals will be subcutaneously injected with ISO (100 mg/kg) at an interval of 24 h for 2 days (on 15th and 16th day). NAS+ISO group (group 4) Rats will be orally treated with NAC (10 mg/kg) dissolved in saline daily for a period of 14 days. On the 15th day the animals will be S.C injected with ISO and a 2nd dose will be administrated on the 16th day. Result: Isoproterenol induced myocardial infarction with notably increase in inflammatory mediators TNF-α and IL-6. Furthermore, SOD is markedly decreased. NAC has a protective effect on cardiac muscle and improve cardiac hemodynamics
Keywords: N-acetylcysteine, |
