Female pattern hair loss, or FPHL, is a disorder that affects millions of women worldwide and may
be emotionally and psychologically taxing in addition to being visually disconcerting. A successful
result can only be achieved with a timely diagnosis and treatment. Diffuse thinning of hair on the
crown and front of the scalp, with the hairline remaining unaffected, characterises female pattern hair
loss (FPHL), the most frequent kind of hair loss in women. It becomes more common as people
become older and is linked to serious mental health issues. It seems that there are several factors
involved in FPHL's pathogenesis, which remains poorly understood. Although androgens have been
suspected, the absence of clinical or biochemical indicators of hyperandrogenism in afflicted women
suggests that other, androgen-independent processes are at play. Increasing evidence suggests that
genetic variants affecting the androgen and oestrogen receptors have a significant role in both its
aetiology and the ability to predict response to anti-androgen therapy. The purpose of this research was
to examine whether or not FPHL is associated with single-nucleotide polymorphisms (SNPs) in the
CYP19A1 gene among Egyptian women.
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