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Dr. Marwa Mohamed Nagib Ebrahim Ahmed :: Publications:

Title:
Effect of the anticancer drug tamoxifen on chronic toxoplasmosis in experimentally infected rats
Authors: Rabab Fawzy Selem1,2, Gehan Abdel Rahman Rashed1, Ashraf Mohamed Abdel Khalek Barakat3, Hasan Mohamed Ali Elfadaly3, Boshra EL-sayed Talha Hussien4, Hemat Salah Mohamed1, Marwa Mohamed Nageeb1 and Ahlam Farag Moharm1
Year: 2019
Keywords: Toxoplasmosis, tamoxifen, breast cancer, serological, Toxoplasma brain cysts, immunomodulatory.
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Marwa Mohamed Nagib Ebrahim Ahmed_Effect_of_the_anticancer_drug_tamoxifen_on_chronic.pdf
Supplementary materials Not Available
Abstract:

Toxoplasma gondii is an opportunistic parasite that can cause severe disorders in infants and pregnant women and can also be lethal in immunologically compromised individuals. During unfit host immune conditions, and as a consequence to latent stage opportunity, the protozoan stimulates serious infection, and signifies higher morbidity and mortality including humans with Acquired Immuno-Deficiency Syndrome (AIDS) or those receiving corticosteroids and cancer chemotherapy. Tamoxifen drug (TAM) is a selective estrogen receptor modulator (SERM), which is commonly used for treatment of breast cancer; it has a known immunomodulatory effects on the patient, especially if administered for a long time as happens in cases of post breast cancer surgery and anti-recurrence prophylactic measures where women might persist to take TAM for years. The research question here was: Can TAM reactivates latent toxoplasmosis? To assess the possible stressful effect of TAM, rats were experimentally infected by T. gondii (RH strain). Three months later, they were treated by oral administration of TAM (10 mg/kg body weight/day) for 7, 14, 21 and 28 days. Tamoxifen effect on toxoplasmosis dynamics was estimated by counting Toxoplasma brain cysts and serological detection of anti-parasitic IgM and IgG all through the experiment time. The results showed an initial insignificant decrease in parasitic burden in groups treated for one week followed by a significant increase in groups treated for 14, 21 and 28 days. There was also a significant decrease in IgM titers in groups treated for one and two weeks while there was a significant increase in IgM titers in groups treated for three and four weeks. There was a significant increase in IgG titrers in groups treated for 14 and 21 days and a border line significant increase in the 1st week while there was non-significant increase in 4th week.

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