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Dr. Marwa Mohamed Nagib Ebrahim Ahmed :: Publications:

Title:
In vitro effect and scanning electron microscopic changes of Nigella sativa loaded chitosan nanoparticles on Schistosoma mansoni adult
Authors: Shereen Magdy Kishik1*, Ahlam Farag Mohram1, Marwa Mohamed Nagib1, Hemat Salah Ali1 and Fatma Fawzi Hendawy2
Year: 2019
Keywords: Schistosoma mansoni, Nigella sativa, chitosan nanoparticles, scanning electron microscope.
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Marwa Mohamed Nagib Ebrahim Ahmed_journal of medicinal plants research.pdf
Supplementary materials Not Available
Abstract:

Nanoparticles can act as drug carriers that can modulate pharmacokinetics, increase bioavailability and target release with minimal toxic effects. The present work aimed to assess the therapeutic effect and electron microscopic changes of Nigella sativa loaded Chitosan Nanoparticles (NSLCN) on adult Schistosoma mansoni in vitro. Adult worms were removed from the portal and mesenteric veins of infected mice after 90 days, and then three to five mature worms including both sexes were cultured. Schistosoma adult was exposed to NSLCN at concentrations of (10, 20, 40, 60, 80, and 100 μg/ml) for 24, and 48 h. Examination for worm viability was done after 24, and 48 h using a stereomicroscope comparing with control negative and control positive groups. The mortality rate in worms reached 88.9% in the group treated with 100 μg and 80 and 84.6% in groups treated with 80 and 60 μg respectively (p-value

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