You are in:Home/Publications/Is serum presepsin levels had accurate discriminative ability for patients vulnerable to develop anastomotic leakage after colorectal anastomosis? A cohort study

Dr. Marwa Seif El Melouk El Sayed :: Publications:

Title:
Is serum presepsin levels had accurate discriminative ability for patients vulnerable to develop anastomotic leakage after colorectal anastomosis? A cohort study
Authors: Mokhtar A. Bahbaha, Marwa S. El-Meloukb, Mysa S. Mostafab,Taher H. Elwana
Year: 2022
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Marwa Seif El Melouk El Sayed_Paper 5.pdf
Supplementary materials Not Available
Abstract:

Objectives Evaluation of the predictive value of serial estimations of serum presepsin (PSP), Creactive protein (CRP), and procalcitonin (PCT) for the development of infective complications and/or anastomotic leakage (AL) after elective colorectal resection with anastomosis for N0M0 colorectal cancers. Patients and methods During 7-year study period, 113 patients underwent colorectal resection; postoperative (PO) morbidities were graded according to the comprehensive complication index (CCI). Five venous blood samples (T1–5) were collected at the time of induction of anesthesia, immediate, 1 day, 3 days, and 5 days after surgery for blood leukocytic count, and calculation of neutrophil-to-lymphocyte ratio and estimation of serum levels of the studied cytokines. Study outcome is the ability of serum cytokines’ levels estimated in T2 sample to predict the possibility for the development of AL. Results Incidence of PO infective morbidities was 31%, incidence of AL was 8.85%, and PO mortality ratewas 2.65%.Operative timewas significantly longer; the total score of the CCI was significantly higher andPOhospital stay was significantly longer for patients who had AL. Patients who developed AL had significantly higher neutrophil-tolymphocyte ratio in T3–5 samples than in the T1 sample. Mean serum levels of the studied cytokineswere significantly higher inT2–5 samples than inT1sample with significantly higher levels in patients who developed AL. Regression analysis defined high serum levels of PSP and PCT in the T3 sample and CRP levels in T5 sample as predictors ofAL and high levels of the three biomarkers in the T3 sample could predict mortality. Automatic linear regression defined high serumPSPlevels in theT3sample and long operative time as significant predictors for high CCI and bad outcome with accuracy rates of 61 and 39%, respectively. Conclusion The level of serum biomarkers could predict AL, but PSP was superior to CRP and PCT. High serum PSP levels in T2 sample can accurately predict high CCI for PO complications.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus