Nutraceuticals have been extensively studied in recent years with the goal of finding safe therapeutics of natural origin instead of relying only on pharmaceuticals. This study aimed to detect the hepato-protective role of moringa and rosemary ethanolic extracts on liver fibrosis induced by thioacetamide(TAA). This study was conducted on 60 male albino rats divided into four groups; control, TAA grroup received thioacetamide (100 mg/kg) intraperitoneal (IP) twice /week for 18 weeks, moringa protected group received moringa ethanolic extract (300 mg/kg) orally daily with TAA, rosemary protected group received rosemary ethanolic extract (200 mg/kg) orally daily with TAA for 18 weeks. Our result showed significant increase in liver alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), malondialdehyde (MDA) and nitric oxide (NO) with significant decrease in reduced glutathione (GSH), super oxide dismutase (SOD) in TAA treated group with high grade of fibrosis which extended to cirrhosis after 18 weeks. Meanwhile, both TAA-moringa and TAA-rosemary treated groups showed improvement in biochemical markers and fibrosis induced by thioacetamide. On conclusion, our results proved that both moringa and rosemary could protect liver against TAA-induced liver fibrosis but rosemary has greater protection than moringa.
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