Background: Methotrexate (MTx), a cytotoxic drug, causes severe damage of small intestine and
alters its oxidative state. Resveratrol (RES) has a powerful anti-oxidant and anti-inflammatory
activities. Aim of the study was to assess and compare the effects of different doses of Resveratrol
on methotrexate induced jejunal toxicity. Material and methods: Forty Two adult male albino
rats were divided into five groups; control group, RES treated group in which rats were subdivided
into two subgroups and received low and high doses of resveratrol (RES) orally, MTx group in
which rats were given methotrexate orally at a dose of 5 mg/kg daily for thirty days, MTx+ RES
L group in which rats received low dose of RES with MTx dose , MTx+ RES H group rats were
received RES in high dose combined with MTx dose. After 30 days of treatment, specimens of
jejunum were obtained for histopathological, biochemical and immunohistochemical examination.
Results: MTx induced epithelial and crypt cellular damage which was corrected by resveratrol
and intestine nearly restored its normal structure, better results were gained with the high dose of
resveratrol. Also, recovery of histopathological and biochemical findings was gained. Conclusion:
this study concluded that Resveratrol could protect jejunum from damaging effect of methotrexate
in a dose dependent manner |
