Background: Soft-tissue expansion technique was first reported in 1957 in a study by Neumann (1) in which a rubber balloon with an external port was used to reconstruct a traumatic ear defect, Currently, there are a wide array of expanders of different shapes and sizes that have been developed to maximize the volume of tissue expansion in any given anatomical location.Aim: Aim of workis to give some light on the application of intra lesional tissue expander as preliminary study..Methods: Between January 2016and January 2018, 30 patients, underwent Intralesional tissue expander in the Banha university hospital, all patients indicated for Intralesional tissue expander were selected from plastic surgery outpatient clinic for this procedure; all were having medium sized lesion in different site in body Results: total of 30 cases (13 male and 17 female) with main age 25.7y were completed, including complete nevus resection and scar removal in different site in the body. The average time required for tissue expansion was 7.7 weeks. Necrosis of the skin flaps did not occur. All wounds were closed directly, with the exception of four cases (13.3%) where complications were occurred of wound dehiscence in 3 cases and infection in one case Conclusion:Intralesional tissue expander is a safe procedure that achieves gratifying results, repairing small- or medium-sized defects with normal surrounding skin tissue. It does not increase the risk of complications or the difficulty of surgery. Compared with traditional expansion techniques, the expansion in-situ technique implants an expander under the lesion, reducing the number of expanders required, the damaged caused and the treatment durationThis novel approach to expansion markedly improves the clinical usefulness of the expanded flap without the requirement for additional incisions or a risk of compromising the blood supply to the extended flaps |