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Dr. Mohamed Elbadawy Abdelgayed Gad Kewan :: Publications: |
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| Title: | The Potential of Organoids in Toxicologic Pathology: Role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment |
| Authors: | Toshinori YOSHIDA, Mio KOBAYASHI, Suzuka UOMOTO, Kanami OHSHIMA, Emika HARA, Yoshitaka KATOH, Naofumi TAKAHASHI, Takanori HARADA, Tatsuya USUI, Mohamed ELBADAWY, Makoto SHIBUTANI |
| Year: | 2022 |
| Keywords: | chemical hepatotoxicity, in vitro, organoids, rat, toxicologic pathologist |
| Journal: | Journal of Toxicologic Pathology |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY |
| Local/International: | International |
| Paper Link: | |
| Full paper | Mohamed Elbadawy Abdelgayed Gad Kewan_advpub_2022-0017.pdf |
| Supplementary materials | Not Available |
| Abstract: |
The development of in vitro toxicity assessment methods using cultured cells has gained popularity for promoting animal welfare in animal experiments. Herein, we briefly discuss the current status of hepatoxicity assessment using human-and rat-derived hepatocytes; we focus on the liver organoid method, which has been extensively studied in recent years, and discuss how toxicologic pathologists can use their knowledge and experience to contribute to the development of in vitro chemical hepatotoxicity assessment methods for drugs, pesticides, and chemicals. We also propose how toxicological pathologists should assess toxicity regarding the putative distribution of undifferentiated and differentiated cells in the organoid when liver organoids are observed in hematoxylin and eosin–stained specimens. This was done while considering the usefulness and limitations of in vitro studies for toxicologic pathology assessment. |
