Objective: to evaluate the platelet indices and their significance in assessment of severity of
preeclampsia and their correlation with pregnancy outcome. Patient and methods: The present study
was a prospective study that was done from January 2012 to March 2013 in EL-Galaa Teaching Hospital
and comprised 200 pregnant women who were: 100 normotensive and 100 preeclampsia (68 cases were
mild preeclampsia and 32 cases were sever preeclampsia), blood samples were analyzed for platelet
indices and the pregnant women were followed up for both maternal and fetal outcome. Results: The
present study found that the platelet count decreased, while MPV, PDW and PLcr increased with
severity of preeclampsia, poor maternal prognosis and poor fetal prognosis. And from ROC curves we
found that in differentiating mild from sever preeclampsia a PLT count cut-off value of 168,000 / mm3
showed a sensitivity of 87.5 % and specificity of 72.1 %, a MPV cut-off value of 10.3 fl showed a
sensitivity of 87.5 % and specificity of 85.3 %, a PDW cut-off value of 16.2 fl showed a sensitivity of
87.5 % and specificity of 85.3 % and a PLcr cut-off value of 29.7 % showed a sensitivity of 87.5 % and
specificity of 83.8 %. We also found in predicting poor maternal prognosis a PLT count cut-off value of
116,000 / mm3 showed sensitivity of 83.7 % and specificity of 88.5 %, a MPV cut-off value of 12.1 fl
showed sensitivity of 83.7 % and specificity of 88.5 %, a PDW cut-off value of 18.7 fl showed
sensitivity of 83.7 % and specificity of 88.5 % and a PLcr cut-off value of 34.7 % showed sensitivity of
83.7 % and specificity of 88.5 %. We also found that in predicting poor neonatal prognosis a PLT count
cut-off value of 128,500 / mm3 showed sensitivity of 92.3 % and specificity of 94.7 %, a MPV cut-off
value of 11.3 fl showed sensitivity of 92.3 % and specificity of 94.7 %, a PDW cut-off value of 17.8 fl
showed sensitivity of 92.3 % and specificity of 94.7 % and a PLcr cut-off value of 32.9 % showed
sensitivity of 92.3 % and specificity of 94.7 %. Conclusion: We found a relationship between platelet
indices and severity of preeclampsia and pregnancy outcome.
[Wael Ahmed Ezzat kamel Ammar, Moharam Abd El Hasseeb Abd El Hei, Mahmoud Ahmed Gehad and Mohamed
Ibrahim Mohamed. Evaluation of platelet indices and their significance in Preeclampsia. Nat Sci
2014;12(3):147-153]. (ISSN: 1545-0740). http://www.sciencepub.net/nature. 21 |
