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Dr. Mohamed ibrahim mohamed ahmed :: Publications:

Title:
Evaluation of platelet indices and their significance in Preeclampsia
Authors: Wael Ahmed Ezzat kamel Ammar1, Moharam Abd El Hasseeb Abd El Hei2, Mahmoud Ahmed Gehad3 and Mohamed Ibrahim Mohamed3
Year: 2014
Keywords: platelet indices, significance, Preeclampsia
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Mohamed ibrahim mohamed ahmed_021_23462ns120314_147_153.pdf
Supplementary materials Not Available
Abstract:

Objective: to evaluate the platelet indices and their significance in assessment of severity of preeclampsia and their correlation with pregnancy outcome. Patient and methods: The present study was a prospective study that was done from January 2012 to March 2013 in EL-Galaa Teaching Hospital and comprised 200 pregnant women who were: 100 normotensive and 100 preeclampsia (68 cases were mild preeclampsia and 32 cases were sever preeclampsia), blood samples were analyzed for platelet indices and the pregnant women were followed up for both maternal and fetal outcome. Results: The present study found that the platelet count decreased, while MPV, PDW and PLcr increased with severity of preeclampsia, poor maternal prognosis and poor fetal prognosis. And from ROC curves we found that in differentiating mild from sever preeclampsia a PLT count cut-off value of 168,000 / mm3 showed a sensitivity of 87.5 % and specificity of 72.1 %, a MPV cut-off value of 10.3 fl showed a sensitivity of 87.5 % and specificity of 85.3 %, a PDW cut-off value of 16.2 fl showed a sensitivity of 87.5 % and specificity of 85.3 % and a PLcr cut-off value of 29.7 % showed a sensitivity of 87.5 % and specificity of 83.8 %. We also found in predicting poor maternal prognosis a PLT count cut-off value of 116,000 / mm3 showed sensitivity of 83.7 % and specificity of 88.5 %, a MPV cut-off value of 12.1 fl showed sensitivity of 83.7 % and specificity of 88.5 %, a PDW cut-off value of 18.7 fl showed sensitivity of 83.7 % and specificity of 88.5 % and a PLcr cut-off value of 34.7 % showed sensitivity of 83.7 % and specificity of 88.5 %. We also found that in predicting poor neonatal prognosis a PLT count cut-off value of 128,500 / mm3 showed sensitivity of 92.3 % and specificity of 94.7 %, a MPV cut-off value of 11.3 fl showed sensitivity of 92.3 % and specificity of 94.7 %, a PDW cut-off value of 17.8 fl showed sensitivity of 92.3 % and specificity of 94.7 % and a PLcr cut-off value of 32.9 % showed sensitivity of 92.3 % and specificity of 94.7 %. Conclusion: We found a relationship between platelet indices and severity of preeclampsia and pregnancy outcome. [Wael Ahmed Ezzat kamel Ammar, Moharam Abd El Hasseeb Abd El Hei, Mahmoud Ahmed Gehad and Mohamed Ibrahim Mohamed. Evaluation of platelet indices and their significance in Preeclampsia. Nat Sci 2014;12(3):147-153]. (ISSN: 1545-0740). http://www.sciencepub.net/nature. 21

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