Objective:Tomeasuretheserum levelofvisfatininpreeclampticEgyptianpregnantwomenand
thepossiblerelationofvisfatinleveltoeachofthemeasuredinsulinresistance,bodymassindex
andhistopathologicalchangesoftheplacentaincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Thepresentstudyresultsrevealedthatpreeclampticmothershadasignificantincreasein
insulinresistancevaluethannormalpregnantwomenwithnosignificantdifferenceinthisvalue
betweenmildandseverepreeclampticsub-groups.Regardingvisfatinlevel,therewasahighly
significantincreaseinvisfatinlevelinpreeclampticwomencomparedwithhealthycontrolsand
alsoincreaseinseverethanmildpreeclampticsub-groups.Correlationanalysispresenteda
significantnegative correlation between maternalvisfatin levelsversusHOMA-IR among
preeclampticgroup,butnorelationhadbeenfoundbetweenvisfatinlevelsandbodymassindex
amongpreeclampticmothers.Histopathologicalexaminationofplacentaerevealedthatinfarctions,
atherosis,hyalinizedareasandTennyParkerschangesweresignificantlyincreasedinpreeclamptic
groupthancontrolgroup.Thepresentstudydidnotfoundanycorrelationsbetweenvisfatinlevels
versushistopathologicalchangesinplacentaeamongpreeclampticmothers.
Conclusions:Hypervisfatinemia maybeoneofthepossibleetiologiesofpreeclampsia.Visfatin
mightbepartofafeedbackmechanism improvinginsulinsensitivity.Preeclampticplacentae
exhibiteddefinitehistopathologicalchangeswhichmaybeattributedtothevascularinsufficiency
ofplacenta |
