Background: Ovarian Stimulation Response (OSR) in polycystic
ovarian syndrome (PCOS) ladies is controversial issues .Aim:
to evaluate outcomes of Fixed Progestin-Primed Ovarian
Stimulation (FPPOS) and Flexible GnRH Antagonist Protocol
(FGnRHan) on OSR and pregnancy outcomes in PCOS ladies
undergone intracytoplasmic sperm injection-frozen embryo transfer
(ICSI-FET). Patients and Methods: A retrospective assessment of
PCOS ladies undergoing ICSI-FET cycles at Riyadh fertility center,
Agouza, Giza Governorate (RFC) and Benha University Hospital
(BUH), over the last 5 years. The frequencies of clinical pregnancy,
continued pregnancy, live births, fertilization, early LH surge, and
other OSR results were the outcomes. Results: of 950 ladies
included, 420 had FPPOS (study group) and 390 (control group)
had the GnRHan protocol. Both groups' baseline metrics showed
similarities. Oocytes that were mature and fertilized showed no
discernible difference between the two groups (P > 0.5). Premature
luteinization was rare in both groups, and there was no statistically
significant difference (P > 0.5). Additionally, there was no
discernible difference in the clinical pregnancy rate per frozen
embryo transfer cycle (FETC) between the FGnRHan and FPPOS
groups (P > 0.5). Also, continuing pregnancy rates, miscarriage
rates, biochemical pregnancy rates, and implantation rates, showed
statistically similarities across the groups (P > 0.05). Although there
was a considerable decrease in cost calculated in local currency (5.8±3.1 vs. 8.8±4.1, p =0.001)
between the FPPOS and FGnRHan groups |
