| Title: | Utility of 4-(isatin-3ylideneamino)benzohydrazide in the synthesis of bioactive N-heterocyclic compounds
MMH Arief, AA Aly, AA Khalil, HI Mohamed, Journal of Chemical and Pharmaceutical Research, 2014, 6 (2): 327-335
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| Authors: | MMH Arief, AA Aly, AA Khalil, HI Mohamed |
| Year: | 2014 |
| Keywords: | Not Available |
| Journal: | Journal of Chemical and Pharmaceutical Research |
| Volume: | 6(2) |
| Issue: | Not Available |
| Pages: | 327-335 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Mohamed M. H. Arief_JCPR-2014-6-2-327-335.pdf |
| Supplementary materials | Not Available |
| Abstract: |
4-(Isatin-3-ylideneamino)benzoic acid, was synthesized and converted into 4-(isatin-3-ylideneamino)benzoyl chloride. Hydrazinolysis of the acid chloride afforded4-(isatin-3-ylideneamino)benzohydrazide. The latter compound was used as a key precursor for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and oxadiazole derivatives via its reaction with different electrophilic reagents. Structures of all synthesized compounds were elucidated from FT-IR, 1H-NMR, mass spectroscopy and elemental analyses. Some of the synthesized heterocycles were screened against selected microbes to test their antimicrobial activity. Keywords: Isatin schiff's bases, benzohydrazide, thiadiazole, pyrazole, antimicrobial activity. |
