Background & aim; Patients who experience repeated episodes of hepatic encephalopathy (HE can have persistent
and cumulative deficits in working memory, response inhibition and learning. There is rising evidence of clinical
connections between vitamin D status and global and particular areas of cognitive function and that vitamin D
insufficiency may be connected with both depression and schizophrenia. This research was aiming to examine the
connection between 25 hydroxy vit D insufficiency and hepatic encephalopathy in patient with cirrhotic liver disease.
Methods: We included a total of 50 patients with liver cirrhosis, who were separated into two equal groups; the Non-HE
group contained 25 instances without HE, and the HE group which included the remaining 25 cases with HE. Results:
Vitamin D exhibited a substantial decline in the HE group, as it had a mean value of 31.22 nmol/l compared to 42.89
nmol/l in the other group. Vitamin D insufficiency was observed in 68 and 96 percent of patients in the Non-HE and HE
groups respectively. Vitamin D levels revealed no significant link with any of the measured variables other from CTP
score, that exhibited a significant negative relationship with the tested vitamin. Using a cut-off value of 37.61, blood
vitamin D level exhibited sensitivity and specificity of 68 and 60 percent respectively for identifying hepatic
encephalopathy in cirrhotic individuals. Conclusion; A substantial connection was discovered between vitamin D
deficiency and the development of HE. The degree of vitamin D insufficiency is highly connected with the severity of
liver functioning state. |
