Prof. Mohamed Mohamedy Ghanem :: Publications:

This study aimed to evaluate the clinical, haematobiochemical and histopathological changes in goats with surgically induced unilateral hydronephrosis. To achieve this aim, eight male castrated goats were divided into two groups. Group A (animals with surgically-induced unilateral hydronephrosis) in which goats were subjected to ligation of the right ureter for 42 days and group B (sham-operated). Clinical examination and haematobiochemical analysis were performed before and after induction (on days 1,7,14,21,28,35 and 42). Histopathological examination of kidneys was carried out at the end of the study. On the 1st day, goats with unilateral hydronephrosis showed depression, arched back , decreased appetite. After that, these clinical signs were ameliorated and the animals restored there apparent health condition. PCV%, Hb content and RBCs count increased during the early periods of the study then returned gradually to normal level by the end of the study. WBCs count was significantly increased allover the time of the study. Significant increase of serum urea, creatinine, uric acid and calcium levels during the early period of the study then gradually decrease. Albumin and total proteins levels were initially decreased but were restored by the end of the experiment. Post-mortem examination of affected kidneys showed dilatation of renal pelvis and calyces with severe atrophy of the parenchyma. Histopathologial examination of affected kidneys revealed severe cystic dilatation of renal tubules and intertubular connective tissue proliferation. We concluded that unilateral hydronephrosis produced significant changes during the early stage which were gradually restored owing to the compensatory activities of the contralateral kidney. Keywords: Ureter,ligation, hydronephrosis, kidney, goats