It is crucial to ensure that hypertensive patients
adhere to their medication regimens to prevent complications that
may result in mortality, as hypertension is an incurable condition.
Consequently, our objective was to ascertain the proportion of
patients who adhered to the use of antihypertensive drugs and
certain factors associated with adherence, as well as to
investigate the efficacy of the MIR-122 gene as a screening
instrument for the identification of hypertensive patients with
inadequate medication adherence. Methods: This prospective
study included 381 patients, seventy females and 311 males,
adherence to treatment was assessed by Morisky Medication
Adherence Scale (MMAS-8). Serum microRNAs were measured
for all studied patients at six months. Results: 149 cases (39.2%)
were adherent to treatment, and 232 patients (60.8%) were not
adherent to treatment. Patients with poor adherence to treatment
had statistically higher Mir-122 expression compared to good
adherent group. Mir-122 expression could predict poor adherence
to treatment, at a cutoff value > 9.4, the sensitivity was 100% and
specificity was 100%, P |
