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| Title: | STUDY OF PLASMA OSTEOPONTIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS WITH AND WITHOUT EVIDENCE OF LUNG FIBROSIS |
| Authors: | Mahmood Alsalahy*MD, Mohammad Hassan**MD, Refaat Altanawy***MD and Anas Yosof**** MD and Mohamed I Abdelfattah MD ***** |
| Year: | 2008 |
| Keywords: | SLE , RA,Osteopontin |
| Journal: | The Egyptuan Jornal of Chest diseases and tuberculosis |
| Volume: | 57 |
| Issue: | 1,2 |
| Pages: | 121-127 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Mohamed Ibrahim Abd Elfatah Mohamed_STUDY OF PLASMA OSTEOPONTIN final.doc |
| Supplementary materials | Not Available |
| Abstract: |
To study the relation of the newly discovered proinflammatory cytokine osteopontin (OPN) to lung fibrosis in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), we selected 18 RA patients ( 7 ♂ and 11♀; 29.28 ± 10.42 years ) and 17 (6 ♂and 11♀, 37.7 ± 7.11 years) and 10 normal controls ( 27.3 ± 9.01 years). 7 of RA and 6 of SLE patients have clinical and radiological evidence of lung fibrosis. FEV1 % predicted, ESR, serum CRP and plasma osteopontin were measured. FEV1 % predicted was significantly lower in patients than controls and in those with fibrosis than in those without in both groups (p< 0.001 and |
