Sevoj1.urane degradation by carbon dioxide absorbents during low -
Jlow anesthesiaforms compound A. which causes nephrotoxicity in rats.
This study was done to evaluate post operative renal and hepatic functions
after patients were administered Sevoj1.urane under conditions designed
to generate high concentration of compound A. Consenting forty
patients ASA physical status I, II with normal pre operative renal and hepatic
function undergoing anesthesia for elective surgery with planned
duration exceeding 2 h. They were randomized to receive Sevoj1.arane
(n=20) or Isoj1.arane (n=20) in oxygen. Total gas flow was iLlmin. opioid
doses were minimized and barium hydroxide lime was used to maximize
anesthetic degradation. Blood and urine were obtained before and 1.2
and 3 days after anesthesia for laboratory evaluation. Sevoflurane and
Isoj1.urane groups were similar with respect to age, weights sex. ASA
status and anesthetic duration (2-4h). There was no significant difference
between anesthetic groups in postoperative serum creatinine. BUN, and
urinary excretion of protein .Post operative alanine and aspartate amino
transferase concentration .were not different between the anesthetic
groups. It is concluded that renal tubular and hepatic effects of 10w-j1ow
Sevoj1.urane and Isoj1.urane were similar as assessed using both conventional
measures of renal and hepaticfunctions .Moderate duration of lowj1.
ow Sevoj1.urane anesthesia, during which compound A formation occurs
appears to be as sqfe as low-j1.ow Isoj1.urane anesthesia |
