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Prof. mohamed khaled mohamed mahfouz moustafa :: Publications:

Biochemical Changes Followed Experimental Respiratory Distress by Benzene Vapours
Authors: Abdel Maksoud H. A, Mahfouz M. K, Omnia M. A, Abdullah M. H, Eltabey M. E and Mohamed G. Elharri
Year: 2019
Keywords: Benzene Exposure; Inflammatory Pathways; Oxidative Stress
Journal: biomedical and pharmacology journal
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Not Available
Supplementary materials Not Available

Monitoring of exposure to chemical matters is seriously needed for evaluating health hazards resulted from its inhalation. The present study was carried out to determine the biochemical, immunological and oxidative stress parameters as well as the possible histological effects of exposure to benzene vapours in male albino rats. Results indicated that; Benzene vapours exposure induced significant increasing in Myeloperoxidase (MPO) enzyme levels. This goes with marked immunologic changes presented by decreases in immunoglobulins; IgA and IgG, along with increases in levels of IgM and IgE. Also, Malondialdehyde (MDA) levels were significantly increased. Meanwhile, reduction in different biochemical parameters including; Superoxide Dismutase (SOD), Catalase (CAT) levels and Glutathione (GSH) content. Lung sections taken showed; Thickening of alveolar septa with chronic inflammation and /or fibrosis, Congested vessels/thick walled vessels and Peri-bronchiolar fibrosis. Hence, the study concluded that; prolonged benzene (BNZ) vapours exposure lead to biochemical, immune disterbance and histopathological changes probably through potentiating oxidative stress and inflammation pathways

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