Medicinal plants have been used since immemorial time to treat and prevent human ailments. Mimusops Larifolia is a medium sized evergreen tree belonging to family Sapotaceae which is widely used in the treatment of different ailments in traditional system of medicine in ancient Egypt. Mimusops Larifolia species was recorded to have several pharmacological activities like antimicrobial, antioxidant, anti-inflammatory, hypotensive, antihyperlipidemic, antitumor as it possess a number of phytochemical constituents which have been identified in this plant. Obesity is a significant risk factor associated with many complications such as cardiovascular diseases, diabetes, osteoarthritis, liver and kidney diseases, pancreatitis, cancer and chronic diseases. Obesity is a chronic disease that develops excessive fat accumulation and increase in body weight and result in increased plasma triglycerides, high LDL cholesterol, low HDL cholesterol, elevated blood glucose level and high blood pressure. High Fat Diet (HFD) supplementation have been used in animal models to induce a significant increase in: serum cholesterol, triacylglycerol, , low density lipoprotein(LDL), lipoprotein a (Lip. A), and increase activity of lipase enzymes On contrast, it exhibited a significant decrease in serum levels of High density lipoprotein (HDL). Mimusops laurifolia Leaves butanolic extract is selected for our investigation against high fat diet- induced hyperlipidemia in rats as it was able to ameliorate stress induced by high fat diet and showed pronounced curative effect aganist hyperlipidemia and deviated serum atherogenic indices towards control levels. The results of the present study suggest that Mimusops laurifolia Leaves extract has the potential to exert curative effect against hyperlipidemia. |
