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Prof. Mohamed Shawky ElSayed Saleh Elbory :: Publications: |
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| Title: | Secretion of glucagon- like peptide-1 (GLP-1) in type 2 diabetic patients: Study of its relation to glucose
lowering effect of dipeptidyl peptidase IV (DPP-IV) inhibitors. |
| Authors: | Atef Ahmed Ebraheem1, Mohammed Shawky El-Sayed1, Roshdy Khalf Allah1, Khaled Mostafa Belal2, Rizk Sayad Rizk Sarhan |
| Year: | 2015 |
| Keywords: | glucagon- like peptide-1, Type2 DM, dipeptidyl peptidase IV (DPP-IV) inhibitors,GLP-1 level, incretin hormone, incretin based therapy. |
| Journal: | Nature and Science |
| Volume: | 2015;13(6) |
| Issue: | Not Available |
| Pages: | 75-87 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | |
| Full paper | Mohamed Shawky ElSayed Saleh Elbory_012_28738ns130615_75_87.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Th aims of this study are to investigate the glycemic efficy and predictive parameters of DPP IV inhibitors therapy in Egyptian subjects with type 2 diabetes. (2) Investigate the level and the determinants that affect the secretion of glucagone like peptide-1(GLP-1) in Type2 diabetic patients. Subjects and Methods: This study was conducted on 70 type 2 diabetes patients【35 males & 35 females】 under known antidiabetic drugs, Their ages range was (30-63y) and average mean (46.31±10.75 y), as well as 20 apparently healthy subject's volunteers served as control 【12 males & 8 females】 with age range (28-50y) and SD (37.40±5.04 y). DPP-4 inhibitors were added to every patient after the start of the study. The patients were followed at monthly interval for 3 months after the beginning of DPP-4 inhibitors therapy. Results: GLP-1 levels were significantly decreased in DM subjects compared to controls (261.33± 9.37 vs.75.48 ± 20.81pg/mL, p |
