ABSTRACT
ackground:Weaimed to studytheplasmaadiponectinlevel as apredictorof
Egyptian type 2 diabetes withandwithout metabolic syndrome. Subjects and
methods: This studywascarried outon70humansdivided into three groups .
GroupIincludedtwentyfivetype2diabeticpatientswithmetabolicsyndrome(10
malesand15females),meanagewas(52.9:t 10.5years).Group11 includedtwentyfive
diabeticpatientswithoutmetabolicsyndrome(20malesand5females),meanagewas(55.8
i9.1years).GroupIIIincludedtwenty normalhealth volunteerssewingascontrol(8males
and 12 females),meanagewas( 48.8i4.2 years).Thorough historytakingandclinical
examinationwasdonetoallsubjectswithstressonageofdevelopmentofDM,durationof
DM,lineoftreatment,waistcircumference,BMI,systolicanddiastolicBP.Thefollowing
laboratoryinvestigationsweredonetoallsubjects fastingandpostprandialbloodglucose
level, plasmainsulinandadiponectin. Result: Plasmaadiponectinlevelwassignificantly
lowerintype2diabeticpatientswithmetabolicsyndromecomparedtobothtype2diabetic
patients withoutmetabolic syndromeandcontrol group.The study showeda significant
negative correlation ofadiponectin withbodymass index( BMI), waist circumference,
systolic anddiastolic bloodpressure , fastingplasmaglucose(FPG)andtwohourspost—
prandialplasmaglucose(PPPG),triglyceride(TG),insulinandhomeostasismodelassessment
(HOMA)amonggroup1patients.Nosignificantcorrelationwaselicitedbetweenadiponectin
level andthese parameters in group II neither diabetic patients norcontrol group. A
significantpositivecorrelationwasdetectedbetweenHDL-cholesterolandadiponectinin
diabetic patients withmetabolicsyndromewhile nosignificantcorrelationwasdetected
betweenadiponectinandHDL-cholesterolinothergroups .
Conclusions: Hypoadiponectinemiacanbeconsidered as acause andacomponentof
metabolicsyndromeanditcanbeconsideredasapredictoroftype2diabetesmellituswith
metabolicsyndromeandnotfortype2diabetesmellitus withoutmetabolicsyndrome. |
