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Prof. Mohamed Sayed Abd el-Rhman Sayed Behalo :: Publications: |
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| Title: | An efficient synthesis of some new 1,4-disubstituted phthalazine derivatives
and their anticancer activity |
| Authors: | Ashraf Farouk Wasfy*, Aly Abdelmaboud Aly and Mohamed Sayed Behalo and Nora Sobhi Mohamed* |
| Year: | 2013 |
| Keywords: | Phthalazin-1-(2H)-One; Acid hydrazide, Isoindol-1,3-dione; Antitumor activity |
| Journal: | Der Pharma Chemica |
| Volume: | 5 |
| Issue: | 2 |
| Pages: | 82-96 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Mohamed Sayed Abd el-Rhman Sayed Behalo_paper 2.pdf |
| Supplementary materials | Not Available |
| Abstract: |
A novel series of phthalazine derivatives bearing isoindol-1,3-dione moiety were synthesized by treating ethyl{4-[4- (1,3-dioxo-1,3-dihydroisoindole-2-yl)-phenyl] phthalazin-1-yloxy}acetate (3) and {4-[4-(1,3-Dioxo-1,3- dihydroisoindol-2-yl)phenyl]phthalazin-1-yloxy} acetic acid hydrazide (7a) with various chemical reagents.The newly synthesized compounds were characterized on the basis of their spectral (1H NMR, 13C NMR, Ms, IR) analyses. In vitro, most of the synthesized derivatives were screened for their antitumor activity against MCF-7 cells using MTT assay. Compounds 16b, 18, 13, 15, 17 showed the most potent cytotoxic effect concluded from their IC50 values 50, 70, 150, 180 and 100 μg/ml respectively. |
