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Prof. Mohamed Sayed Abd el-Rhman Sayed Behalo :: Publications: |
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| Title: | Synthesis and Evaluation of Pyrido[2,3-d]pyrimidine and 1,8-Naphthyridine Derivatives as Potential Antitumor Agents |
| Authors: | Mohamed S. Behalo* and Giuseppe Mele |
| Year: | 2017 |
| Keywords: | Not Available |
| Journal: | J. Heterocyclic Chem |
| Volume: | 54 |
| Issue: | Not Available |
| Pages: | 295 |
| Publisher: | Wiley |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Mohamed Sayed Abd el-Rhman Sayed Behalo_pyridopyrimidine.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Abstract New series of pyrido[2,3-d]pyrimidine and 1,8-naphthyridine derivatives were synthesized from 2-amino-6-(phenoxathiin-2-yl)-4-(thiophene-2-yl) nicotinonitrile as starting material, and their structures were characterized on the basis of the spectral data. Most of the synthesized compounds were evaluated for their cytotoxic activity against two cancer cell lines, namely, breast cancer Michigan Cancer Foundation-7 (MCF-7) and prostate cancer human prostatic carcinoma cell line (PC-3) using MTT assay. Some of these compounds showed potent cytotoxic effect concluded from their IC50 values. |
