You are in:Home/Publications/Green synthesis of 1,3,4-oxadiazole derivatives based on N-arylidene-2-(1-oxo-4-(4-phenoxyphenyl)phthalazin- 2(1H)-yl)acetohydrazide as potential antitumor agents

Prof. Mohamed Sayed Abd el-Rhman Sayed Behalo :: Publications:

Title:
Green synthesis of 1,3,4-oxadiazole derivatives based on N-arylidene-2-(1-oxo-4-(4-phenoxyphenyl)phthalazin- 2(1H)-yl)acetohydrazide as potential antitumor agents
Authors: Mohamed S. Behalo | Ebtsam S. El Said
Year: 2021
Keywords: 1,3,4-oxadiazoleو antitumor agents
Journal: journal of heterocyclic chemistry
Volume: 57
Issue: 1
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Mohamed Sayed Abd el-Rhman Sayed Behalo_New Microsoft Word Document.docx
Supplementary materials Mohamed Sayed Abd el-Rhman Sayed Behalo_New Microsoft Word Document.docx
Abstract:

Design of a new series of 1,3,4-oxadiazole derivatives was achieved in good yield via treatment of N-arylidene-2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-2(1H)-yl) acetohydrazide with cerium (IV) ammonium nitrate as a catalyst. They can be formulated also using one-pot reaction of 2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-2 (1H)-yl)acetohydrazide, aromatic aldehyde and cerium (IV) ammonium nitrate in dichloromethane. The structural formulas of all synthesized products were elucidated based on their elemental and spectral analyses. In addition, MTT assay was used to evaluate antitumor activity of the synthesized molecules and some of them showed potent activity in comparison with Doxorubicin as a standard drug.

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