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Prof. Mohamed Sayed Abd el-Rhman Sayed Behalo :: Publications: |
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| Title: | Green synthesis of 1,3,4-oxadiazole derivatives based on
N-arylidene-2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-
2(1H)-yl)acetohydrazide as potential antitumor agents |
| Authors: | Mohamed S. Behalo | Ebtsam S. El Said |
| Year: | 2021 |
| Keywords: | 1,3,4-oxadiazoleو antitumor agents |
| Journal: | journal of heterocyclic chemistry |
| Volume: | 57 |
| Issue: | 1 |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Mohamed Sayed Abd el-Rhman Sayed Behalo_New Microsoft Word Document.docx |
| Supplementary materials | Mohamed Sayed Abd el-Rhman Sayed Behalo_New Microsoft Word Document.docx |
| Abstract: |
Design of a new series of 1,3,4-oxadiazole derivatives was achieved in good yield via treatment of N-arylidene-2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-2(1H)-yl) acetohydrazide with cerium (IV) ammonium nitrate as a catalyst. They can be formulated also using one-pot reaction of 2-(1-oxo-4-(4-phenoxyphenyl)phthalazin-2 (1H)-yl)acetohydrazide, aromatic aldehyde and cerium (IV) ammonium nitrate in dichloromethane. The structural formulas of all synthesized products were elucidated based on their elemental and spectral analyses. In addition, MTT assay was used to evaluate antitumor activity of the synthesized molecules and some of them showed potent activity in comparison with Doxorubicin as a standard drug. |
