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Prof. Mohamed Mohamed Soliman Ahmed :: Publications:

Title:
Comparative Studies on Effect of High Fish and Corn Oil Diet on Lipid Profiles, PPAR-α and FAS mRNA in Swiss Mice
Authors: Ismail Tamer Ahmed, Mohamed M.A. Hussein, Mohamed M. Soliman, Alhumiany A. Abdelrahman
Year: 2012
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Mohamed Mohamed Soliman _Fish oil paper.doc
Supplementary materials Not Available
Abstract:

The hypolipidemic actions of oils reflect their quality and safety for human health. So, the aim of the present study is to test the lipidemic effects of two oil supplements. Experimental mice were fed on normal diet and foods enriched in corn oil or fish oil for one month. Lipid profiles were measured and gene expression of PPAR-α and fatty acid synthase were semi-quantitated using RT-PCR analysis. Results showed significant increase in lipid profiles in corn oil fed group. LDL-c and blood glucose were decreased while HDL-c was significantly increased in fish oil fed group compared to mice fed normal diet. FAS mRNA expression was higher in corn oil fed group while PPAR- was high in fish oil fed group. In conclusion, dietary supplementation of fish oil alters lipid profiles and expression of lipid metabolizing enzymes. Further studies are needed to examine safety of fish oil under high supplemental condition.

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