The present study conducted to test the effect of Nigella Sativa (NS, 5 mg kg-1 of body weight), or g-
irradiated Nigella Sativa (GRNS) on the changes of blood component profiles, liver, kidney functions and
immune cytokines secretion in male Wistar rats. Moreover, the possible protection by propolis (200 mg kg-1
B. W.) on the changes induced by NS and GRNS was examined. Results revealed that both NS and GRNS
administration for two weeks induced changes in blood, GPT, GOT and urea levels and co-administration
with propolis significantly ameliorated such changes. Also, liver histology showed numerous vacuolar
degeneration and fatty changes in g-irradiated groups which disappeared in presence of propolis. Kidney
histology of NS administered rats showed less lymphocytic infiltration, while GRNS groups showed
desquamation in the cytoplasm of the renal tubules, hemorrhage in the renal corpuscle and lymphocytic
infiltration which disappeared when propolis given together with GRNS. Finally propolis induced protective
effect on the changes induced in TNF-α and IL-10 secretion by either NS or GRNS in Wistar rats. In
conclusion, the findings of present study clarified the protective effect of propolis on changes induced by g-
irradiated NS on blood, liver, kidney and cytokines changes in Wistar rats. |
