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Dr. Mohamed Said Moustafa Soliman :: Publications:

Hepatitis C Virus Associated Primary Hepatocellular Carcinoma in a Non-Cirrhotic Liver.
Authors: Mazen Albeldawi, Mohamed Soliman, Rocio Lopez, Nizar Zein
Year: 2009
Keywords: Not Available
Journal: ACG conference San Diego,
Volume: 53
Issue: 2
Pages: 1-18
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Mohamed Said Moustafa Soliman_Print.docx
Supplementary materials Not Available

The case of a 71-year-old man with a primary hepatocellular carcinoma in a non-cirrhotic liver is reported. There were no risk factors of hepatocellular carcinoma (HCC)-like liver cirrhosis, alcohol drinking, tobacco smoking, exposure to vinyl chloride, thorotrast, aflatoxin or α1-antitrypsin deficiency. Serologically, the patient was positive for antibodies to the hepatitis B virus (anti-HBc, anti-HBs) and for anti-hepatitis C virus (HCV) antibodies. Virologically, positive and negative strands of HCV RNA could be detected in the patient's serum and tumorous liver tissue by reverse transcription polymerase chain reaction as a sign of persistent HCV replication. Histologically, the HCC was completely surrounded by liver tissue which showed the signs of nodular regenerative hyperplasia. Indeed, the mechanism of hepatocarcinogenesis remains to be clarified. However, this case supports the observation that HCC may also develop in patients with HCV infection without preexisting liver cirrhosis.

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