Background/Aims: Patients with cirrhosis are usually prone to develop bacterial infections, primarily spontaneous bacterial peritonitis (SPB), which is present in 15-25% of patients with cirrhosis and ascites. Diagnosis is based on a fixed defined cutoff PMNs count in the ascitic fluid which is more than 250 polymorphonuclear cells (PMNs) / mm3. The use of additional markers which are rapidly and easily applicable, may add significant benefit for predicting the development of spontaneous bacterial peritonitis and achieving diagnostic accuracy. The objective of this study is to measure mean platelet volume (MPV) and platelet cluster of differentiation molecule 40 ligand (CD40L) and to evaluate their usefulness in the diagnosis of SBP in cirrhotic patients.
Materials and Methods: This study comprised 80 cirrhotic patients with ascites and 10 healthy subjects as a control group. Who were subdivided into 40 patients with SBP and 40 without SBP who were enrolled at Hepatology, Gastroenterology and Infectious diseases department and Shebin-Elkom Teaching Hospital from April 2015 to October 2015. The diagnosis of liver cirrhosis and ascites were based on clinical, biochemical and ultrasonographic findings. Mean platelet volume (MPV) and platelet CD40L were measured.
Results: A significant increase in MPV and platelet CD40L observed in SBP group compared to non SBP (P < 0.001). At cutoff value of 8.71 fl MPV had 68.75% sensitivity and 80% specificity for diagnosis of SBP. At cutoff value of 4, 81 ng/ml platelet CD40L in serum had 62% sensitivity and 80% specificity for detecting SBP.
Conclusion: Mean platelet volume (MPV) and platelet cluster of differentiation molecule 40 ligand (CD40L) are useful marker in the diagnosis of SBP in cirrhotic patients.
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