J. Egypt. Soc. Parasitol. 27 (1), April(1997).
Histopathological and immunohistochemical studies of skeletal muscle in mice experimentally infected with Schistosoma mansoni.
Amira E., Abdel Gaffar, Tahani M. Essa and Mona E. Nasr
Histopathological, histochemical and immunohistochemical studies were carried out on the skeletal muscles of mice experimentally infected with Schistosoma mansoni throughout 20 weeks post infection. Histopathological changes were delected from the 13th week post infection inspite of absence of Schistosoma mansoni eggs. There were definite enzymatic changes dehydrogenase, non spectcific esterase and acid and alkaline phosphatases. These changed started from the 14th week post infection. S. mansoni immune complex deposits were detected in the muscles from the 9th week post infection. Positive correlation was found between the degree of immune complex deposition and histopathological and histochemical changes. The study confirmed the role of immue infection (Schistosoma mansoni).
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