The pharmacokinetics of cefquinome was studied following
intravenous and intramuscular (single & repeated)
injection
.
Cefquinome was assayed by High performance liquid chromatography
method
Following a single intravenous injection of 2 mg/kg body
weight of cefquinome in normal chickens, plasma concentration
-
time
curve was best described by a three compartments model with
elimination half
-
life (t
0.5(β)
= 0.712 hour), volume of distribution
(V
dss
=389.23 ml/kg) and total clearance of the drug (C
l
tot
= 0.048
ml/kg/min). Following a single intramuscular administration of
2
mg/kg body weight cefquinome in normal chickens,
the
peak
plasma
concentration (
C
max
) was 3.53
μg/ml was achieved at a maximum time
(T
max
) of 2.80 hour. The mean systemic bioavailability was 106.82%.
The
plasma
concentrations of cefquinome following repeated intramuscular administration of
2 mg/kg body weight once daily for three cons
ecutive days in normal and experimentally
S
almonella
e
ntretidis
infected chickens showed a lower significant values recorded in
experimentally
Salmonella
e
ntretidis
infected chickens than in normal ones. Cefquinome
showed accumulative behavior in plasma of
chickens.
Cefquinome was assayed in plasma,
heart, liver, lung, kidney, breast muscle, thigh muscle and skin after 24, 48, 72, 96, 120
and144 hours post last dose following administration of 2 mg/kg body weight every 24 hours.
Results of this study indica
ted that cefquinome was useful for treatment of
Salmonella
e
ntretidis
infections in chickens. |
